Low-dose atropine
~30-70% ↓ progressionAntimuscarinic drop at night. Slows axial elongation by a receptor-mediated scleral/retinal effect, largely independent of accommodation.
- Concentrations
- 0.01%, 0.025%, 0.05% (compounded in the US)
- Best candidate
- Age ~4-12 at onset, documented progression; usable alongside optical methods
- Evidence
- LAMP: dose-dependent, 0.05% best efficacy-to-tolerability. US CHAMP trial did not show a benefit for 0.01% on its primary endpoint.
- Watch-outs
- Dose-dependent photophobia and near blur; rebound spurt on abrupt cessation (worse at higher strengths); confirm concentration and beyond-use date each refill