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Sulfacetamide / prednisolone

Anti-inflammatory · Rx
Trade namesBlephamide, Vasocidin
Drug classAntibiotic + corticosteroid (combination)
StrengthSulfacetamide 10% + prednisolone acetate 0.2% (or phosphate 0.25%)
AvailabilityRx
Mechanism of actionSulfonamide antibacterial plus corticosteroid.
Indication / reason for useBlepharitis / blepharoconjunctivitis with an inflammatory component; marginal keratitis.
Usual adult dosing1-2 drops q4h; ointment TID-QID + bedtime. Shake suspension.
PreservativeBAK
Contact lensesNo lens wear during treatment.
Common / important adverse effectsStinging, sulfonamide hypersensitivity (incl. SJS), IOP rise, cataract.
Contraindications & cautionsSulfonamide allergy; HSV epithelial keratitis, fungal/mycobacterial infection.
Pregnancy / lactationAvoid near term.
Chair-side reference only. Dosing, contraindications and pregnancy guidance here are not exhaustive. Confirm against the current prescribing information and the patient’s full history before prescribing or advising.

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