Netarsudil / latanoprost
Glaucoma · Rx
Trade namesRocklatan
Drug classFixed combination, ROCK inhibitor + prostaglandin
StrengthNetarsudil 0.02% + latanoprost 0.005%
AvailabilityRx
Mechanism of actionIncreases conventional outflow (netarsudil) and uveoscleral outflow (latanoprost), targets both drainage routes; the most effective fixed combination in trials.
Indication / reason for useOpen-angle glaucoma / ocular hypertension needing substantial IOP reduction.
Usual adult dosing1 drop in the affected eye(s) once daily in the evening.
PreservativeBAK 0.02%
Contact lensesRemove lenses; reinsert after 15 minutes.
Common / important adverse effectsConjunctival hyperemia (common), subconjunctival hemorrhage, cornea verticillata, plus prostaglandin lash/iris/periorbital changes.
Contraindications & cautionsAs for the PGA class.
Pregnancy / lactationAvoid where possible.
Practice notesOnce-daily dosing is an adherence advantage over BID combinations.
Chair-side reference only. Dosing, contraindications and pregnancy guidance here are not exhaustive. Confirm against the current prescribing information and the patient’s full history before prescribing or advising.